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March
27 - 31, 2004 |
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Program Agenda
Click here for printable version of program agenda.
Saturday, March 27, 2004
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| 4:00 - 10:00pm | Check-in |
| 4:00 - 7:00pm |
Registration |
| 7:00 - 7:05pm |
Welcome - J. David Lambeth |
| 7:05 - 8:00pm |
Keynote Address
Sue Goo Rhee, NHLBI, NIH
Intracellular messenger function of hydrogen peroxide |
| 8:00 - 10:00pm |
Reception
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Sunday, March 28, 2004
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| 10:00 - 12:30pm |
Brunch |
| 12:00 - 1:00pm |
Registration |
| 1:00 - 3:00pm |
Session
I: The Phagocyte NADPH Oxidase
Session Leader: Dirk Roos
Mary Dinauer, Indiana University School
of Medicine,
Riley Hospital for Children
The biology of the phagocyte NADPH oxidase and its enzymatic regulation by the regulatory subunits
Edgar Pick, Tel Aviv University
Guanine nucleotide exchange factor (GEF)-dependent activation of the NADPH oxidase by GTP and ATP - Revisiting some dogmas
Gary M Bokoch, The Scripps Research Institute
The molecular basis for adhesion-mediated suppression of reactive oxygen species generation by human neutrophils
Robin van Bruggen, Sanquin Research
Continuous translocation of Rac2 and the NADPH oxidase component p67phox during phagocytosis
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| 3:00 - 3:30pm |
Break |
| 3:30 - 5:30pm |
Session
II: Post-translational Regulation of Nox 1-4
Session Leader: William Nauseef
Thomas Leto, NIAID, NIH
Characterization of Non-myeloid multi-component oxidases
Hideki Sumimoto, Kyushu University
Molecular mechanism for activation of Nox1 and Nox4
J. David Lambeth, Emory University
Nox3 and the resurgence of polytheistic paganism
Terry Kay Epperson, University of Texas Health Science Center at San Antonio
The C-terminal cytoplasmic domain of gp91phox and NOX1 determines activity with the regulatory subunits NOX01 and NOXA1
|
| 6:00pm |
Dinner/beach party |
Monday, March 29, 2004
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| 7:30 - 8:30am |
Breakfast |
| 8:30 - 10:20am |
Session
III: Biology and Pathology of Nox Explored through Animal Models
Session Leader: J. David Lambeth
Botond Banfi, University Hospitals of Geneva
The in vivo function of Nox1
Darren Ritsick, Emory University
What animal models tell us about biological roles of Nox/Duox
Karine Laude, Emory University
Phenotypic characteristics of mice with vascular smooth muscle targeted overexpression of p22phox
Rhian M. Touyz, Clinical Research Institute of Montreal
Angiotensin II-dependent chronic hypertension and cardiac hypertrophy are independent of the
gp91phox subunit of NAD(P)H oxidase
|
| 10:20 - 10:45am |
Break |
| 10:45 - 1:00pm |
Posters I |
| 1:00 - 2:00pm |
Lunch |
| 2:00 - 4:00pm |
Free time |
| 4:00
- 6:00pm |
Session
IV: Pathophysiology of Nox in Cardiovascular Disease
Session Leader: David Harrison
Bernard Lassegue, Emory University
The role of Nox1 and p22phox in angiotensin II-induced hypertension
Alison Cave, King's College London
Role of NADPH oxidases in cardiac hypertrophy and failure
Harald Schmidt, Rudolf-Buchheim-Institut fuer Pharmakologie
Role of different Nox isoforms in cardiovascular disease models and their pharmacological modulation
Tomasz J. Guzik, University of Oxford
Role of NADPH oxidases in coronary artery disease: relationship to endothelial dysfunction
|
| 6:00 - 7:30pm |
Dinner |
| 7:30
- 9:00pm |
Session
V: Biology and Pathophysiology of Calcium-Regulated Nox/Duox
Session Leader: Corinne Dupuy
Kark-Heinz Krause, Geneva University Hospital
NOX5: what is a Ca(2+)-activated NADPH oxidase doing in human lymphocytes?
Francoise Miot, Universitie Libre de Bruxelles
Characterization of DUOX in the thyroid: Regulation and mechanism(s) of activation
Carrie Ris-Stalpers, Academic Hospital in Amsterdam
Congenital hypothyroidism and mutations in the thyroid oxidase system
Stanislas Morand, Institut National de la Sante et de le Recherche Medicale
Targeting to the plasma membrane of the Duox2 N-terminal region
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Tuesday, March 30, 2004
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| 7:30 - 8:30am |
Breakfast |
| 8:30 - 10:20am |
Session
VI: Pathophysiology of Nox in Cancer, Growth and Innate Immunity
Session Leader: Robert Clark
Ulla G. Knaus, The Scripps Research Institute
Regulation of Nox4-mediated ROS generation
Kaxuhito Rokutan, University of Tokushima,
Pathophysiology of Nox1 in the gastrointestinal tract
Nicholas H. Heintz, University of Vermont
Nox1 promotes proliferation of mouse lung epithelial cells through redox-dependent
activation of cyclin D1 expression
Tohru Kamata, Shinshu University School of Medicine
The superoxide-generating oxidase Nox1 is functionally necessary for Ras oncogene transformation
|
| 10:20 - 10:45am |
Break |
| 10:45 - 1:00pm |
Posters II |
| 1:00 - 2:00pm |
Lunch |
| 2:00 - 4:00pm |
Free Time |
| 4:00 - 6:00 pm |
Session
VII: Nox in the Cardiovascular System and Diabetes
Session Leader: Kathy Griendling
Barry Goldstein, Jefferson Medical College of Thomas Jefferson University
Role of Nox4 in insulin-stimulated hydrogen peroxide generation and insulin signal transduction
Francis Miller, University of Iowa
Smooth muscle cell Nox4 in atherosclerosis
Lula L. Hilenski, Emory University
Cell-cell contact-dependent localization of activated VEGF receptor and NAD(P)H oxidase in
endothelial cells: Implication for a mechanism of growth control by contact inhibition
Ralf P. Brandes, J.W. Goethe-University
Direct interaction of the novel Nox proteins with p22phox for the formation of a functionally
active NADPH oxidase
Patrick J. Pagano, Henry Ford Health System
Perivascular Delivery of an Adenoviral Construct Expressing an NAD(P)H Oxidase Inhibitor Attenuates Angiotensin II (AngII)-induced Mouse Carotid Hypertrophy
| 7:00pm |
Banquet |
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Wednesday, March 31, 2004
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| 7:30 - 8:30am |
Breakfast |
| 9:00 - 11:00am |
Session
VIII: Nox and Reactive Oxygen Species Signalling
Session Leader: Sue Goo Rhee
Pascal Goldschmidt-Clermont, Duke University
Rac1 Regulation of the cardiovascular system
Yves C. Gorin, University of Texas Health Science Center at San Antonio
Arachidonic acid-dependent activation of Nox4 NAD(P)H oxidase mediates angiotensin II-Induced mesangial
cell protein systhesis via activation of Akt/PKB and ERK1/2
Tsukasa Kawahara, University of Tokushima
Participation of p41nox and small GTPase Rac1 in Helicobacter pylori lipopolysaccharide-triggered
activation of NADPH oxidase 1 in cultured gastric mucosal cells
Henry J Forman, University of California Merced
Feed-forward signaling by the respiratory burst of alveolar macrophages
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| 11:00 - 11:30am |
Business Meeting |
| 11:30 - 12 Noon |
Check out |
| 12:00 - 1:00pm |
Lunch |
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